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CAS number 60-87-7
Chemical Formula: C17H20N2S
For the treatment of allergic disorders, and nausea/vomiting.
Like other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. The relief of nausea appears to be related to central anticholinergic actions and may implicate activity on the medullary chemoreceptor trigger zone.