Product Description
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties. It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studie [2, 3, 5]. Aceclofenac potently inhibits the cyclo-oxygenase enzyme (COX) that is involved in the synthesis of prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever. It is orally administered for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Aceclofenac belongs to BCS Class II as it possesses poor aqueous solubility [2]. It displays high permeability to penetrate into synovial joints where in patients with osteoarthritis and related conditions, the loss of articular cartilage in the area causes joint pain, tenderness, stiffness, crepitus, and local inflammation Aceclofenac is also reported to be effective in other painful conditions such as dental and gynaecological conditions In 1991, aceclofenac was developed as an analog of a commonly prescribed NSAID, Diclofenac, via chemical modification in effort to improve the gastrointestinal tolerability of the drug. Indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
High-Quality NSAID for Pain ManagementAceclofenac Powder provides proven efficacy in pain and inflammation control, making it a reliable active pharmaceutical ingredient (API) for formulation in tablets and other dosage forms. Its high purity and stringent control on impurities ensure safety and efficient therapeutic action.
Strict Compliance and Quality AssuranceEvery batch of Aceclofenac Powder is tested according to international pharmacopeial standards, including advanced HPLC and IR verification for identity, and full impurity profiling. Low residue on ignition and heavy metal content further underscore its exceptional quality.
Optimal Packaging and StorageTo maintain product integrity, Aceclofenac Powder is delivered in 25 kg fiber drums with double-layer polyethylene liners. It must be stored in a cool, dry, and well-ventilated environment, ensuring a long shelf life and optimal stability for end use.
FAQs of Aceclofenac powder:
Q: How is Aceclofenac Powder typically used in pharmaceutical applications?
A: Aceclofenac Powder serves as the active ingredient in a variety of analgesic and anti-inflammatory medications, formulated primarily into tablets and caplets for pain and inflammation management.
Q: What quality controls are in place for Aceclofenac Powder?
A: This product undergoes stringent quality checks, including HPLC assay (99.0%101.0% purity), identification via IR and HPLC, and impurity profiling to ensure total impurities do not exceed 0.5%. Residue on ignition, chloride, and heavy metals are also tightly monitored.
Q: Where should Aceclofenac Powder be stored to maintain its potency?
A: It should be stored in a cool, dry, and well-ventilated place, preferably in its original tightly-sealed packaging. Proper storage helps retain its stability for up to five years.
Q: What are the benefits of using Aceclofenac Powder in pharmaceutical formulations?
A: Aceclofenac offers effective relief from pain and inflammation, backed by high purity, low impurity content, and established safety under recommended guidelines, making it a dependable choice for drug manufacturers.
Q: How is Aceclofenac Powder packaged for export and distribution?
A: It is supplied in 25 kg fiber drums lined with double-layer polyethylene bags, preventing contamination and preserving product quality during transportation and storage.
Q: When does Aceclofenac Powder expire, and how long can it be stored?
A: The shelf life of Aceclofenac Powder is five years if the container remains sealed and proper storage conditions are maintained.
Q: What safety precautions should be considered when handling Aceclofenac Powder?
A: While Aceclofenac is non-poisonous as directed, handling should follow standard safety procedures for pharmaceutical powders, and it should be kept away from moisture and incompatible substances.