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Amlodipine besylate

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Amlodipine besylate Price And Quantity

Minimum Order Quantity 1 kg Kilograms
Price Or Price Range INR

Amlodipine besylate Trade Information

FOB Port mumbai
Payment Terms Cheque Telegraphic Transfer (T/T) Paypal
Supply Ability 100 Kilograms kg Per Week
Delivery Time 1 Week
Main Export Market(s) Western Europe Australia North America Eastern Europe Middle East Africa Central America South America Asia
Main Domestic Market All India

Product Description

CAS number

88150-42-9

Chemical Formula

C20H25ClN2O5

For the treatment of hypertension and chronic stable angina.Amlodipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium decreases the contractile activity of arterial smooth muscle cells and results in vasodilation. The vasodilatory effects of amlodipine result in an overall decrease in blood pressure. Amlodipine is a long-acting CCB that may be used to treat mild to moderate essential hypertension and exertion-related angina (chronic stable angina). Another possible mechanism is that amlodipine inhibits vascular smooth muscle carbonic anhydrase I activity causing cellular pH increases which may be involved in regulating intracelluar calcium influx through calcium channels.