Anastrozole

Product Description

CAS number: 120511-73-1

Chemical Formula: C17H19N5

Anastrozole is a drug indicated in the treatment of breast cancer in post-menopausal women. It is used both in adjuvant therapy (i.e. following surgery) and in metastatic breast cancer. It decreases the amount of estrogens that the body makes. Anastrozole belongs in the class of drugs known as aromatase inhibitors. It inhibits the enzyme aromatase, which is responsible for converting androgens (produced by women in the adrenal glands) to estrogens. For adjuvant treatment of hormone receptor positive breast cancer , as well as hormonal treatment of advanced breast cancer in post-menopausal women. Has also been used to treat pubertal gynecomastia and McCune-Albright syndrome; however, manufacturer states that efficacy for these indications have not been established.

Pharmaceutical Standards and Safety

Anastrozole meets rigorous pharmacopeial and ICH guidelines, ensuring its safety and efficacy for medicinal applications. It is tested for purity, single impurities, heavy metals, and microbial limits, guaranteeing a high-quality API suitable for pharmaceutical formulations. With loss on drying not surpassing 0.5% and heavy metals maintained below 0.001%, the product stands out for its reliable composition and safety profile.


Physical and Chemical Properties

This API appears as a white or almost white crystalline solid and offers optimal solubility in ethanol, methanol, and acetone, though it is only slightly soluble in water. With a molecular formula of C17H19N5 and weight of 293.37 g/mol, Anastrozoles chemical identity is confirmed by infrared spectroscopy (IR) analyses, complying with reference standards at every stage. The melting point is consistent at 81-82C, and the compound remains odorless during handling.


Optimal Storage and Handling

To preserve Anastrozoles quality and stability, it is packaged in securely sealed plastic drums, safeguarding from moisture and light. Recommended storage conditions include keeping the API in a cool, dry environment, away from direct sunlight. When stored as instructed, the shelf life extends up to two years, maintaining all pharmacological and physical properties essential for manufacturing and distribution.